Selection of scientific articles using the Bio-Logic Solution Changers

Charged residues in the GABA-A receptor beta-2 subunit are crucial for efficient receptor activation.
Kash TL, Dizon MJ, Trudell JR, Harrison NL. 
J Biol Chem. 2003 Nov 10 {eprint ahead of publication) PMID: 10810076

Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice.
Barberi T, Klivenyi P, Calingasan NY, Lee H, Kawamata H, Loonam K, Perrier AL, Bruses J, Rubio ME, Topf N, Tabar V, Harrison NL, Beal MF, Moore MA, Studer L. 
Nat Biotechnol. 2003 Oct;21(10):1200-7. Epub 2003 Sep 21. PMID: 14502203

The actions of sevoflurane and desflurane on the gamma-aminobutyric acid receptor type A: effects of TM2 mutations in the alpha and beta subunits.
Nishikawa K, Harrison NL. 
Anesthesiology. 2003 Sep;99(3):678-84. PMID: 12960553

A highly conserved aspartic acid residue in the signature disulfide loop of the alpha 1 subunit is a determinant of gating in the glycine receptor.
Schofield CM, Jenkins A, Harrison NL. 
J Biol Chem. 2003 Sep 5;278(36):34079-83. Epub 2003 Jun 25. PMID: 12826676

Hemoglobin metabolites mimic benzodiazepines and are possible mediators of hepatic encephalopathy.
Ruscito BJ, Harrison NL. Blood. 2003 Aug 15;102(4):1525-8. Epub 2003 Apr 24. PMID: 12714506

Effects of isoflurane on gamma-aminobutyric acid type A receptors activated by full and partial agonists.
Topf N, Jenkins A, Baron N, Harrison NL. 
Anesthesiology. 2003 Feb;98(2):306-11. Erratum in: Anesthesiology. 2003 Mar;98(3):803. PMID: 12552186

Coupling of agonist binding to channel gating in the GABA(A) receptor.
Kash TL, Jenkins A, Kelley JC, Trudell JR, Harrison NL.
Nature. 2003 Jan 16;421(6920):272-5. PMID: 12529644

Molecular volume determines the activity of the halogenated alkane bromoform at wild-type and mutant GABA(A) receptors. Kash TL, Jenkins A, Harrison NL. 
Brain Res. 2003 Jan 17;960(1-2):36-41. PMID: 12505655

Tryptophan scanning mutagenesis in TM4 of the GABA(A) receptor alpha1 subunit: implications for modulation by inhaled anesthetics and ion channel structure.
Jenkins A, Andreasen A, Trudell JR, Harrison NL. Neuropharmacology. 2002 Sep;43(4):669-78. PMID: 12367612

Volatile anesthetic actions on the GABAA receptors: contrasting effects of alpha 1(S270) and beta 2(N265) point mutations.
Nishikawa K, Jenkins A, Paraskevakis I, Harrison NL.
Neuropharmacology. 2002 Mar;42(3):337-45. PMID: 11897112

Methionine 286 in transmembrane domain 3 of the GABAA receptor beta subunit controls a binding cavity for propofol and other alkylphenol general anesthetics. Neuropharmacology.
Krasowski MD, Nishikawa K, Nikolaeva N, Lin A, Harrison NL.
2001 Dec;41(8):952-64. PMID: 11747900

Expression of glycine receptors in rat sensory neurons vs. HEK293 cells yields different functional properties.
Kung AY, Rick C, O'Shea S, Harrison NL, McGehee DS.
Neurosci Lett. 2001 Aug 31;309(3):202-6. PMID: 11084076

Anesthetic properties of 4-iodopropofol: implications for mechanisms of anesthesia.
Lingamaneni R, Krasowski MD, Jenkins A, Truong T, Giunta AL, Blackbeer J, MacIver MB, Harrison NL, Hemmings HC Jr.
Anesthesiology. 2001 Jun;94(6):1050-7. PMID: 11085597

General anesthetic potencies of a series of propofol analogs correlate with potency for potentiation of gamma-aminobutyric acid (GABA) current at the GABA(A) receptor but not with lipid solubility.
Krasowski MD, Jenkins A, Flood P, Kung AY, Hopfinger AJ, Harrison NL.
J Pharmacol Exp Ther. 2001 Apr;297(1):338-51. PMID: 11259561

Evidence for a common binding cavity for three general anesthetics within the GABAA receptor.Jenkins A, Greenblatt EP, Faulkner HJ, Bertaccini E, Light A, Lin A, Andreasen A, Viner A, Trudell JR, Harrison NL.
J Neurosci. 2001 Mar 15;21(6):RC136. PMID: 11245705

Arg-274 and Leu-277 of the gamma-aminobutyric acid type A receptor alpha 2 subunit define agonist efficacy and potency.
O'Shea SM, Harrison NL.
J Biol Chem. 2000 Jul 28;275(30):22764-8. PMID: 10801806

Propofol increases agonist efficacy at the GABA(A) receptor.
O'Shea SM, Wong LC, Harrison NL.
Brain Res. 2000 Jan 10;852(2):344-8. PMID: 10678761

The actions of ether, alcohol and alkane general anaesthetics on GABAA and glycine receptors and the effects of TM2 and TM3 mutations.
Krasowski MD, Harrison NL. 
Br J Pharmacol. 2000 Feb;129(4):731-43. PMID: 10683198

Agonist gating and isoflurane potentiation in the human gamma-aminobutyric acid type A receptor determined by the volume of a second transmembrane domain residue.
Koltchine VV, Finn SE, Jenkins A, Nikolaeva N, Lin A, Harrison NL.
Mol Pharmacol. 1999 Nov;56(5):1087-93. PMID: 10531417

Propofol and other intravenous anesthetics have sites of action on the gamma-aminobutyric acid type A receptor distinct from that for isoflurane.
Krasowski MD, Koltchine VV, Rick CE, Ye Q, Finn SE, Harrison NL.
Mol Pharmacol. 1998 Mar;53(3):530-8. PMID: 9495821

Neurosteroids act on the GABA(A) receptor at sites on the N-terminal side of the middle of TM2.
Rick CE, Ye Q, Finn SE, Harrison NL.
Neuroreport. 1998 Feb 16;9(3):379-83. PMID: 9512375

Trichloroethanol modulation of recombinant GABAA, glycine and GABA rho 1 receptors.
Krasowski MD, Finn SE, Ye Q, Harrison NL.
J Pharmacol Exp Ther. 1998 Mar;284(3):934-42. PMID: 9495852

A deficit of functional GABA(A) receptors in neurons of beta 3 subunit knockout mice.
Krasowski MD, Rick CE, Harrison NL, Firestone LL, Homanics GE.
Neurosci Lett. 1998 Jan 9;240(2):81-4. PMID: 9486477

Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.
Mihic SJ, Ye Q, Wick MJ, Koltchine VV, Krasowski MD, Finn SE, Mascia MP, Valenzuela CF, Hanson KK, Greenblatt EP, Harris RA, Harrison NL.
Nature. 1997 Sep 25;389(6649):385-9. PMID: 9311780

Alpha subunit isoform influences GABA(A) receptor modulation by propofol. Neuropharmacology.
Krasowski MD, O'Shea SM, Rick CE, Whiting PJ, Hadingham KL, Czajkowski C, Harrison NL.
1997 Jul;36(7):941-9. PMID: 9257938

Mice devoid of gamma-aminobutyrate type A receptor beta3 subunit have epilepsy, cleft palate, and hypersensitive behavior.
Homanics GE, DeLorey TM, Firestone LL, Quinlan JJ, Handforth A, Harrison NL, Krasowski MD, Rick CE, Korpi ER, Makela R, Brilliant MH, Hagiwara N, Ferguson C, Snyder K, Olsen RW.
Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):4143-8. PMID: 9108119

A single point mutation in the pore region of the epithelial Na+ channel changes ion selectivity by modifying molecular sieving.
S. Kellenberger, I. Gautschi, and L. Schild
(1999) Proc. Natl. Acad. Sci. USA 96:4170-4175.

On the molecular basis of ion permeation in the epithelial Na+ channel.
S. Kellenberger, N. Hoffmann-Pochon, I. Gautschi, E. Schneeberger, and L. Schild
(1999) J. Gen. Physiol. 114:13-30.

Kinetic Analysis of Block of Open Sodium Channels by a Peptide Containing the Isoleucine, Phenylalanine, and Methionine (IFM) Motif from the Inactivation Gate
Galen Eaholtz,* William N. Zagotta,§ and William A. Catterall
J. Gen. Physiol., Volume 111, Number 1, January 1, 1998 75-82

Tetracaine Reports a Conformational Change in the Pore of Cyclic Nucleotide-gated Channels
Anthony A. Fodor, Kevin D. Black, and William N. Zagotta
J. Gen. Physiol. 1997 110: 591-600

Gating and Conduction Properties of a Sodium-activated Cation Channel from Lobster Olfactory Receptor Neurons A.B. Zhainazarov, B.W. Ache
Journal of Membrane Biology Volume 156 - Number 2, (1997) pp: 173-190

Interdomain Interactions Underlying Activation of Cyclic Nucleotide-Gated Channels.
Michael D. Varnum and William N. Zagotta
Science, 278, 110-113 (1997)

Mechanism of tetracaine block of cyclic nucleotide-gated channels.
Fodor AA, Gordon SE, Zagotta WN
J Gen Physiol 109 (1): 3-14 (Jan 1997)

Mechanism of action of K channel openers on skeletal muscle KATP channels.
FORESTIER, C., PIERRARD, J. and VIVAUDOU, M.
J. Gen. Physiol. (1996), 107, 489-502.

Subunit interactions in the activation of cyclic nucleotide-gated ion channels.
Varnum MD, Zagotta WN
Biophys J 70 (6): 2667-2679 (Jun 1996)

Modification by protons of frog skeletal muscle KATP channels : Effects on ion conduction and nucleotide inhibition.
VIVAUDOU, M. and FORESTIER, C.
Journal of Physiology 486, 629-645 (1995).

Molecular mechanism for ligand discrimination of cyclic nucleotide-gated channels.
Varnum MD, Black KD, Zagotta WN
Neuron 15 (3): 619-625 (Sep 1995)

Intracellular protons control the affinity of skeletal muscle ATP-sensitive K+ channels for potassium-channel-openers.
FORESTIER, C., DEPRESLE, Y. and VIVAUDOU, M.
FEBS Letters 325, 276-280 (1993)